lääkesuunnittelu

name

• lääkesuunnittelu

Works about lääkesuunnittelu

• A computational approach towards sirtuin inhibitors :
• A farewell to flat biology : three-dimensional cell culture models in cancer drug target identification and validation
• Application of analytical techniques in quality control of printed pharmaceutical dosage forms :
• Beneficial effects of SIRT1 activation in skeletal muscle and adipose tissue
• Bioinformatic identification of disease driver networks using functional profiling data
• Biomimetic interfaces for surface sensitive drug discovery techniques
• Cell-based bioluminescent high-throughput screening methods in antibacterial drug discovery
• Comparison of disaccharides and polyalcohols as stabilizers in freeze-dried protein formulations
• Computational studies of biomolecular screening and interactions
• Cytochrome P450-selective prodrugs and inhibitors
• Design and synthesis of GPR55 and cannabinoid CB2 receptor ligands
• Designing effective lead molecules against solid tumors with inadequate treatment options : the efficacy problem
• Development of potent and selective inhibitors of enzymes involved in endocannabinoid inactivation
• Discovery of selective small molecule inhibitors towards human Diphtheria toxin-like mono ADP-ribosyltransferase
• Dissecting the pathophysiology of cardiovascular risk factors by means of genetics
• Endocannabinoid hydrolyzing enzymes :
• Farmaseuttisen kemian perusteet
• Field-based proteochemometric models derived from 3D protein structures :
• Hypoxia-inducible factor prolyl 4-hydroxylase-2 in glucose and lipid metabolism and atherosclerosis
• Identification of epigenetic targets in prostate cancer for therapeutic development
• Imaging Alzheimer’s disease beta-amyloid pathology in transgenic mouse models using positron emission tomography
• Immunogenicity of rotavirus VP6 oligomeric structures for use as a candidate rotavirus vaccine
• Implications of bacterial viruses on pathogenic bacteria : from natural microbial communities to therapeutic applications
• Influenza virus-host interactions and their modulation by small molecules
• Inhibition of herpes simplex virus infection with RNA interference
• Insights into retinal drug delivery
• Luminescence-based assay methods in drug discovery
• Nanofibrillar cellulose in drug delivery
• Non-linear label-free optical imaging of cells, nanocrystal cellular uptake and solid-state analysis in pharmaceutics
• Peptide based modulators of prostate specific kallikrein-related peptidases 2 and 3
• Pharmaceuticals' strategic interactions : three essays in corporate finance
• Physically and chemically modified cellulose for drug delivery :
• Polyamine analogues as anticancer agents
• Potential of the osteoclast's proton pump as a drug target in osteoporosis
• PPAR agonists in modulating the inflammatory properties of macrophages
• Principles of targeting sex steroid receptors in cancer drug research & development
• Protozoan and metazoan carbonic anhydrases :
• Screening of marine natural products and their synthetic derivatives for antimicrobial and antiproliferative properties
• Significance of the norovirus G11.4 genotype as a cause of acute gastroenteritis in Finnish children, and the production of a candidate virus-like particle vaccine
• Significance of the norovirus GII.4 genotype as a cause of acute gastroenteritis in Finnish children, and the production of a candidate virus-like particle vaccine
• Small molecule modulators of amine oxidation, nuclear receptor signaling and glucuronidation : 3-phenylcoumarin as a scaffold of interest
• Strategies to enhance drug delivery to the brain : biological studies with large amino acid transporter 1 (LAT1) in prodrug design
• Structure and function of charge deficient polyamines : the latest generation of isosteric charge deficient spermine analogues
• Studying sirtuin inhibitors with in silico and in vitro approaches
• The alpha[sub]2C-adrenoceptor as a neuropsychiatric drug target : PET studies in human subjects
• The role of drug metabolism in drug discovery and development : case ospemifene
• The spindle assembly checkpoint as a drug target : novel small-molecule inhibitors of aurora kinases
• VAP-1 as drug target in inflammation : structural features determining ligand interactions
• Virtual screening : development of a novel structure-based method
• Virus-like particles for vaccine development