Histological characteristics and gene expression profiling of Dupuytren's disease

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  • Histological characteristics and gene expression profiling of Dupuytren's disease
P60049

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Histological characteristics and gene expression profiling of Dupuytren's disease

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  • Histological characteristics and gene expression profiling of Dupuytren's disease

Histological characteristics and gene expression profiling of Dupuytren's disease

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  • 9789526211671
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  • Histological characteristics and gene expression profiling of Dupuytren's disease

Histological characteristics and gene expression profiling of Dupuytren's disease

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  • 9789526211664
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  • Histological characteristics and gene expression profiling of Dupuytren's disease

Histological characteristics and gene expression profiling of Dupuytren's disease

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  • Histological characteristics and gene expression profiling of Dupuytren's disease

Histological characteristics and gene expression profiling of Dupuytren's disease

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  • Histological characteristics and gene expression profiling of Dupuytren's disease
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Histological characteristics and gene expression profiling of Dupuytren's disease

datePublished
  • 2016
description
  • Artikkeliväitöskirjan yhteenveto-osa ja 3 eripainosta.
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  • propertyID: FI-MELINDA value: 009587825
isbn
  • 9789526211664
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name
  • Histological characteristics and gene expression profiling of Dupuytren's disease
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  • 94 sivua, 21 sivua useina numerointijaksoina
P60048
P60050
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  • location: Oulu organizer: Oulun yliopisto
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Histological characteristics and gene expression profiling of Dupuytren's disease

bookFormat
datePublished
  • 2016
description
  • Artikkeliväitöskirjan yhteenveto-osa.
  • Nimeke nimiösivulta.role in proliferation processes such as in fibrotic conditions.To evaluate a possible chromosomal imbalance behind the aetiology of the disease, eighteen DD palmar fascia samples were compared with two reference samples. However, we were not able to detect any chromosomal imbalance in the DD samples. The method used was Oligonucleotide aCGH Agilent's 60-mer oligonucleotide-based microarray according to the manufacturer's instructions, which can reveal gains and losses of approximately 35 kilobases in the whole genome. The result does not exclude copy number changes entirely; a small presence of aberrant cells will not be detected if the change is less than 50%.In conclusion, we revealed elements in DD tissue that would enable us to predict the nature of the disease; whether the disease is aggressive with a stronger tendency to recur. Histological differences could be detected, and this can be used to benefit patients. As a new element, ROR2 was discovered in DD tissue.The genome-wide analysis with the 44K oligonucleotide-based array method revealed no changes of DNA number sequences.
identifier
  • propertyID: FI-MELINDA value: 009587283
isbn
  • 9789526211671
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name
  • Histological characteristics and gene expression profiling of Dupuytren's disease
numberOfPages
  • 1 verkkoaineisto (98 sivua)
P60048
P60050
publication
  • location: Oulu organizer: Oulun yliopisto
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